After nearly 11 years of follow-up, long-term administration of imatinib was shown to be associated with prolonged control of chronic myeloid leukemia and no cumulative or late toxic effects have emerged.
A boy with hydroxyurea-refractory sickle cell anaemia underwent bone marrow transplantation with autologous hematopoietic stem cells transduced by a lentivirus to express an anti-sickling ß-globin variant. No sickle cell crises occurred in the following 15 months.
Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples Luciano G Martelotto, Timour Baslan, Jude Kendall, Felipe C Geyer, Kathleen A Burke, Lee Spraggon, Salvatore Piscuoglio, Kalyani Chadalavada, Gouri Nanjangud, Charlotte K Y Ng, Pamela Moody, Sean D'Italia, Linda Rodgers, Hilary Cox, Arnaud da Cruz Paula, Asya Stepansky, Michail Schizas, Hannah Y Wen, Tari A King, Larry Norton, Britta Weigelt, James B Hicks & Jorge S Reis-Filho
SYNDEMIC is a synergistic epidemic. The term developed by Merrill Singer in the mid-1990s. Disease concentration, disease interaction, and their underlying social forces are the core concepts. Disease co-occurrence, with or without interactions, is known as comorbidity. The difference between "comorbid" and "syndemic" is "comorbidity tends to focus on the nosology, while syndemic focuses on communities experiencing co-occurring epidemics that additively increase negative health consequences." The hallmark of a syndemic is the presence of two or more disease states that adversely interact with each other, negatively affecting the mutual course of each disease trajectory, enhancing vulnerability, and which are made more deleterious by experienced inequities. A new Series on this topic published in Lancet.
